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CAR T-Cell Therapy HCP Guide – Side Effects: Cerebral Edema
Cerebral edema (brain swelling) is another very serious and often fatal adverse event encountered with CAR T treatment.
Eight cerebral edema-related deaths have been reported...
CAR T-Cell Therapy HCP Guide – Side Effects: Neurotoxicity
Neurotoxicity, which can occur in tandem with cytokine release syndome (CRS), includes symptoms such as aphasia, tremor, and seizures. Other reported CNS events include...
CAR T-Cell Therapy HCP Guide – Side Effects: Cytokine Release Syndrome (CRS)
Cytokine Release Syndrome (CRS) is one of the most common, but worrisome, serious side effects of CAR T-cell therapy. How does it occur? After...
CAR T-Cell Therapy HCP Guide – Overview: Side Effects from CAR T-Cell Therapy
CAR T-cell therapy is a potent investigational treatment used in patients with high tumor burden. A positive response to CAR T-cell therapy leads to...
CAR T-Cell Therapy HCP Guide – Solid Tumor Research: Progress to Be Made
While CAR T-cell therapy in hematologic cancers is impressive, the fact remains that most deadly cancers are solid tumors like lung, breast, or colon...
CAR T-Cell Therapy HCP Guide – Pivotal Trial: Aggressive B-Cell Non-Hodgkin Lymphoma
Aggressive B Cell Non-Hodgkin Lymphomas
About 90% of lymphoma cases start in the B cells. The C19 tumor target that is sought by the...
CAR T-Cell Therapy HCP Guide – Cancer Targets
Gene Therapy to the Rescue
The first investigational oncology gene therapy known as a chimeric antigen receptor (CAR) T-cell therapy is rapidly moving...
CAR-T Cell Therapy HCP Guide – KTE-C19 Studies – Zuma 6 Trials
CAR T-Cell Therapy and Checkpoint Inhibitors Together?
CAR T-cell therapy positive response rates in aggressive leukemias and lymphomas are impressive, but relapse or progression does...
CAR-T Cell Therapy HCP Guide – KTE-C19 Studies – Zuma 3 & 4 Trials
CAR T-Cell Therapy for ALL
Axicabtagene ciloleucel (KTE-C19) is also being investigated in the ZUMA-3 and ZUMA-4 trials for treatment of relapsed/refractory acute lymphoblastic leukemia...
CAR-T Cell Therapy HCP Guide – KTE-C19 Studies – Zuma 2 Trials
ZUMA-2 Trial: Mantle Cell Lymphoma
In the ZUMA-2 trial, Kite Pharma is also evaluating the treatment of relapsed/refractory mantle cell lymphoma (MCL) with KTE-C19. MCL...
