CAR T-Cell Therapy HCP Guide – Patient Delivery: The Preinfusion Conditioning Regime

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Before the bioengineered T-cells are reinfused, the patient undergoes a conditioning chemotherapy regimen to reduced the competing T-cell population (lymphodepletion), lower the tumor burden and help reduce serious complications such as cytokine-release syndrome (CRS).

Agents used in conditioning regimens have varied in studies but have frequently included:

  • Cyclophosphamide
  • A combination of fludarabine and cyclophosphamide (FC regimen) The FC regimen seems to be commonly used.
  • Other agents include pentostatin and bendamustine.

Researchers note that the best conditioning regimen is still under study, but studies have shown an improved 6-month progression-free survival as well as a longer duration of CAR T-cell survival for patients who receive a preinfusion conditioning regimen. Zhang and colleagues reported that the 6-month progression free survival (PFS) was 94.6% for patients given the lymphodepletion regimen prior to cell infusion, significantly higher than 54.5% in patients without lymphodepletion.

Learn More: Adverse Events Linked With CAR T-Cell Therapy

Sources for CAR-T Cell Therapy HCP Guide by Drugs.com